-
Categories
-
Tags
3DQ laboratory aarhus university Aarthi Chary Academia adolescents adult aging AI AI-Assisted Hospital AIDS all department meeting allergies allergy AML amyloid analytics anesthesia Angioplasty antagonism anthrax anti-hunger Antiretroviral Therapy Aortic Disorders Aortic Stenosis aortitis arterial hypertension arthritis Artificial Intelligence asthma at risk Atrial Fibrillation autoimmune diseases babies babies in uganda back pain bacteria bbq behavior behavioral science benefit concert BeWell big data billing Biobanks Biodesign Bioethics bioinformatics Biomedical Data biomedical ethics biomedical informatics biomedical model Biomedical Research Biomedical science biomedicine biotechnology bioterrorism blackburn blood and marrow transplantation blume lecture BMT bollyky botulism Brain Injury Breast Cancer breast cancer outcomes Breast Oncology brian brian blackburn budgeting bugs burnout bv“Genomic Landscape of Uveal Melanoma”“Genomic Landscape of Uveal Melanoma” Cancer cancer care Cancer data cancer outcomes cancer prevention cancer research cancer screening Cancer stage Information cancer treatment Cancer treatment needs cannabis Cardiac Care Cardiology Cardiovascular Cardiovascular Disease Cardiovascular Institute cardiovascular medicine Cardiovascular Research cardiovascular surgery care management Careers CareEverywhere platform case case presentation case studies CEDAR Project cell biology Cell Rearch census bureau center for digital health Center for Innovation in Global Health changing etiology chemical and social exposure chicago chief residents childhood malnutrition children China chronic fatigue chronic illness cigarettes circulatory support claims data clerkship clinformatics clinical Clinical Case Presentation clinical cases Clinical Data Clinical excellence clinical protocol Clinical Quality Clinical Research clinical skills clinical studies clinical trial design Clinical trials Clinicians CME Collecting large data colon cancer combat injury Community Health compensation Computer-interpretable Guidelines Concussion conflict in medicine connected health consult consumer health care contemplation by design continuing medical education Continuity Continuity of Care Coronary artery disease Coronary Disease coronary stenting Critical Care culture Culture Change CVI Cybele Renault cystic fibrosis cystric fybrosis Cytogenetics danish populations data data center data quality data science data sets Data sharing data training Data Warehouse datamart datasets date of death dean dean winslow decision making demography denied medical claims Dermatology design Device Development diabetes diabetes research diagnoses diagnostics dialysis Digestive Disease Clinical Conference digital health digital media digital phenotype digitized health discussion disease Disease States Diversity domain-specific donor dora ho dosing Drug Combination Challenge Drug Development Drug efficacy drug safety Drug Synergy DVT easter medicine Ebola ECHO economics Education efficient health care delivery EHR EHR data EHR technology elderly care electronic health information Electronic Health Records electronic medical records Electronic Medical Reocrds electronic phenotyping Electronic Records emi lesure emotion end of life endocarditis endocrinology endovascular environment-gene interaction environmental influences EPIC epidemiology epigentics esophagus ethics evolution extremely large databases eye faculty faculty forum faculty happy hour family id FDA Regulations febrile federal statistical research fellows didactic fever first 1000 days fmig Food Systems Informatics forgive for good frederic luskin frontiers in diabetes fsrdc gastroenterology gastroenterology and hepatology gender gender norm gender variables gene expression General GI genetic disease Genetics genetics and environment genome genomic data Genomics geographic medicine gi GI Oncology GI Research Conference Gina Suh global aging Global Health Global Oncology GMD Grand Roun Grand Round Grand Rounds guatemala guide GWAS health health and disparities Health and Wellness Health Behaviors health care Health care information Health data Health Disparities health educational systems Health Equity Health Information technology health plus plus health policy health related data health research health research and policy health sciences health statistics Healthcare healthcare innovation healthcare research heart heart health hemapoetic Hematology Hematopoiesis hepatitis c hepatology Heterogeneous public data HIE high blood pressure high-risk Histone proteins HIV HIV Journal Club holiday hormones hospitalist human development Human genome Human Gut human mind hypertension IBD ichs ID ID Grand Rounds ID Lecture Series ild illness immigration immune Immune system immunity immunocompromised immunodeficiency Immunology Immunotherapy inclusive workplace IncRNAs india infecious diseases infections Infectious Diseaes infectious disease infectious Diseases Infectious GI infertility inflammation Informatics information technology innovative institutional approval insulin resistance Internal Medicine internet industry internet of things intra-abdominal ipums ISEXS jack rowe james faghmous jo robinson john groopman Joint replacement jonathan fisher jonathan kolstad Jonathan Li jose jose g montoya junior faculty kalanithi award kappagoda kidney Kidney Disease Kidney Transplant kidneys lab-based research language of functioning leadership leadership in healthcare learning collaborative Learning healthcare life adversity liver cancer liver inflammation lung cancer lupus lymphoma machine learning MachineProse Malaria marcell alsan Marfan Syndrome marquitta white maternal health MD MDS meaningful work medical education Medical Image medical practice medical technology Medicine Meditation Melanoma meningitis mental health Mentorship meta analysis meta-data methamphetamines microbes microbiology Microbiome Mindfulness minorities misdiagnoses MMSc mobile devices mobile medical apps modern medicine Molecular Genetics montoya MPNs multi drug Myeloma myocarditis national immigration national registry Natural language processing NCDs nchs neourology Nephrology Neurobiology neurodegeneration neurology neuroplasticity neurosciences Neurosurgery neutropenia new england jouranl of medicine newborn survival nicole bush NIH Clinical Center nipah nlp nodules noninvasive NSCLC nutrition obesity Observational Health Sciences and Informatics Oncology Ontologies optum organ transplant Organ Transplantation orthopedics Osteoarthritis Osteoblast otolaryngology outcomes Pain Management pain relief Palliative Care parkinsons Pathology Pathophysiology pathways Patient Adherence Patient Care Patient Education Patient Safety patient value Patietn Saety paul payer claims data pcp PCPH Pediatric Nephrology Pediatric Oncology pediatrics performance art PERFUSE perioperative care personalized health technology Personalized Medicine PGS Pharmacogenomics pharmacy PhDs Phenotype Phil Grant Philip Grant phsyiology physical health physician burnout Physician wellbeing physiology Placebo Placebo Effect plague plasticity policies policy policy researchers population population based health Population Health population health sciences populations post docs post treatment Postoperative Outcomes PPCM practice-based research precision health precision medicine preclinical work pregnancy prenatal Prescription drugs presence Preventative Medicine prevention Prevention Research Primary Care procedure codes professional stress project baseline promotion Prostate cancer provider tables Psychiatry Psychology PTSD Public Health Publication models Pulmonary pulmonary and critical care pulmonary critical care Pulmonary Fibrosis Pulmonary Hypertension quality care Quality Improvement quality oncology care quantitative imaging Radiogenomics Radiology Radiology notes Radiomics randomized controlled trial reappointment redwood city Regenerative Medicine reproductive medicine research residency resistant respirator returning rheumatology RIP risk factors robert shafer sampling santa rosa community health Sarcoma sccr school of medicine seminar SEPI sepsis sex sex differences shanthi simulation modeling skin skin/soft tissue sleep sleep health smallpox social social genomics social media social mobility societal aging socioculture soft tissue spine issues Sports Medicine SPRC staff stanford diabetes research center Stanford-China Staphylococcal Infection state of department state of the department statistical learning statistical research stem cells stress stress test Stroke students study suicide prevention superior canal dehiscence supplements Surgery Symposium synapse Systems teaching teaching medicine technology testosterone Thoracic Oncology tick borne Tobacco and Drug Use trainees Transcriptional Data translational translational research Transplant Immunology transplantation Travel travelers traveling treatment trial management tropical diseases Tropical Medicine truven Tuberculosis tularemia ucla undiagnosed unique data sets unknown origin updates Urologic Malignancy UTI Vascular Physiology vasculitis Veterans Viral Threats Virology virus Viruses wall street water related wearable technologies Web Ontology Language western medicine WikiDoc winslow women's health work life balance working groups youth zika

Presenter: Jonathan Chen, MD, PhD
Assistant Professor of Biomedical Informatics
Stanford University
Jonathan H Chen MD, PhD is a physician-scientist with professional software development experience and graduate training in computer science. He continues to practice Internal Medicine for the concrete rewards of caring for real people and to inspire his research focused on mining clinical data sources to inform medical decision making.
Chen co-founded a company to translate his Computer Science graduate work into an expert system to solve organic chemistry problems, with applications from drug discovery to a practical education tool distributed to students across the world. To gain first-hand perspective in tackling the greater societal problems in health care, he completed medical training in Internal Medicine and a VA Research Fellowship in Medical Informatics. He has published influential work in venues including the New England Journal of Medicine, JAMA, JAMA Internal Medicine, Bioinformatics, Journal of Chemical Information and Modeling, and the Journal of the American Medical Informatics Association, with research awards and recognition from the NIH Big Data 2 Knowledge initiative, National Library of Medicine, American Medical Informatics Association, Yearbook of Medical Informatics, and American College of Physicians, among others.
In the face of ever escalating complexity in medicine, integrating informatics solutions is the only credible approach to systematically address challenges in healthcare. Tapping into real-world clinical data streams like electronic medical records with machine learning and data analytics will reveal the community’s latent knowledge in a reproducible form. Delivering this back to clinicians, patients, and healthcare systems as clinical decision support will uniquely close the loop on a continuously learning health system. Dr. Chen’s group seeks to empower individuals with the collective experience of the many, combining human and artificial intelligence approaches to medicine that will deliver better care than what either can do alone.
Refer to Dr. Chen’s web-page for additional in-depth bio information, publication lists, CV, etc.
http://web.stanford.edu/~jonc101
Francesco Vallania,
Postdoctoral Scholar,
ITI, Stanford University
ABSTRACT:
Post-translational modifications of histone proteins and exchanges of histone variants at chromatin are central to the regulation of nearly all DNA-based biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we present a highly multiplexed mass cytometry analysis to profile the global levels of a broad array of chromatin modifications in primary human immune cells at the single-cell level. Our data reveal markedly different cell type- and hematopoietic lineage-specific chromatin modification patterns. Differential analysis between younger and older adults shows that aging is associated with increased heterogeneity between individuals and elevated cell-to-cell variability in chromatin modifications. Analysis of a twin cohort unveils heritability of chromatin modifications and demonstrates that aging-related chromatin alterations are predominantly driven by non-heritable influences. We present a powerful platform for chromatin and immunology research. Our discoveries highlight the profound impacts of aging on chromatin modifications.