Apr
3
Tue
ID Lecture Series: “Tuberculosis Part 1” @ Li Ka Shing Center, LK208
Apr 3 @ 8:00 am – 9:00 am

Presenter: Gary Schoolnik, MD; Professor of Medicine (Infectious Diseases), Emeritus

Apr
10
Tue
ID Lecture Series: “Tuberculosis Part 2” @ Li Ka Shing Center, LK208
Apr 10 @ 8:00 am – 9:00 am

Presenter: Gary Schoolnik, MD; Professor of Medicine (Infectious Diseases), Emeritus

ID Lecture Series: Tuberculosis Part 2 @ Li Ka Shing Center, LK208
Apr 10 @ 8:00 am – 9:00 am

Presenter: Gary Schoolnik, MD; Professor of Medicine (Infectious Diseases), Emeritus

Jun
7
Thu
BMIR Research In Progress: Hayley Warsinske “Prospective validation of a three-gene signature for tuberculosis diagnosis, predicting progression and evaluating treatment response” @ MSOB, Conference Room X275
Jun 7 @ 12:00 pm – 1:00 pm

Hayley Warsinske
Hayley Warsinske,
Postdoctoral Scholar,
ITI, Stanford

Abstract:
The World Health Organization (WHO) has identified the need for a non-sputum based triage test for active tuberculosis disease that can be used to identify those who need further testing and ultimately treatment. We investigated whether our previously described 3-gene TB score could identify individuals with active tuberculosis (ATB) prior to seeking care (“active case detection”). We further investigated how the 3-gene TB score correlated with the timing of disease onset, disease severity, and response to treatment. This study consisted of a prospective nested case-control trial, Brazil Active Screening Study (BASS; 2016), and re-analysis of data from two prospective cohort studies, the Adolescent Cohort Study (ACS; 2005-2007) and the Catalysis Treatment Response Cohort (CTRC; 2010-2013). The 3-gene TB score diagnosed ATB patients with high accuracy. In the ACS, the 3-gene TB score predicted progression from LTBI to ATB 6 months prior to positive sputum test.  In the CTRC, the 3-gene TB score correlated with glycolytic activity ratio of PET-CT at baseline and at end of treatment. In the CTRC, the 3-gene TB score at baseline predicted the likelihood of prolonged sputum positivity following treatment initiation and treatment response at 6 months Collectively, across all cohorts, the 3-gene TB score identified ATB patients with 90% sensitivity and 70% specificity, and had 99% negative predictive value (NPV) at 5% prevalence. The 3-gene TB score closely approaches the WHO target product profile benchmarks for non-sputum-based triage test at high NPV. These performance characteristics make it a potential test for ruling out ATB and for monitoring disease status.

Jun
21
Thu
ID Grand Rounds: “In search of a prognostic biomarker for active tuberculosis” @ Lane Building, L151
Jun 21 @ 4:00 pm – 5:00 pm

Presenter: Gary Schoolnik, MD; Professor of Medicine (Infectious Diseases), Emeritus

Zoom Meeting ID: 858 696 854

Aug
30
Thu
ID Grand Rounds: “Tuberculosis in Immunocompromised Hosts” @ Lane Building, L151
Aug 30 @ 4:00 pm – 5:00 pm

Presenter: Aruna Subramanian, MD and Jenny Aronson, MD. Zoom Meeting ID: 858 696 854

Apr
7
Thu
SCCR Virtual Science Series: Modern Sleep Medicine: How I Learned to Stop Worrying and Love my Sleep @ Zoom Meeting Link
Apr 7 @ 9:00 am – 11:00 am
SCCR Virtual Science Series: Modern Sleep Medicine: How I Learned to Stop Worrying and Love my Sleep @ Zoom Meeting Link

Presenter: Dr. Jamie Zeitzer, PhD

Click HERE to Register!

Zoom Class Link

The mission of the Stanford Center for Clinical Research (SCCR) includes offering educational resources, training, and support for investigators and research staff.  We have invited the Associate Professor of Psychiatry and Behavioral Sciences at Stanford Center for Sleep Medicine, Dr. Jamie Zeitzer, PhD, to provide you with fundamental aspects of sleep and circadian physiology, common disruptors, and countermeasures to these disruptions, as well as current and future developments in the field.

At the conclusion of this class, you will be able to:
• Understand the biological underpinnings of sleep and circadian rhythms
• Understand common types of sleep disruptions
• Understand countermeasures to sleep disruptions

Attendance is open to all research staff.

About the Instructors:

Dr. Jamie Zeitzer, PhD, is an associate professor of Psychiatry and Behavioral Sciences and the co-director of the Center for Sleep and Circadian Sciences at Stanford University. He also holds a position as a health science specialist at the VA Palo Alto Medical Center. He has more than 25 years of research experience examining sleep and circadian rhythms in humans as well as animal models. His current research mainly focuses on the impact of light on human behavior, circadian-based sleep disorders, and the use of wearables to improve human health.

BRN OPTIONAL 

Spectrum is an approved provider by the California Board of Registered Nursing, Provider Number CEP15435 for 2 contact hour(s).
To receive your certificate with BRN credit, you are required to complete an evaluation at the conclusion of this class.
BRN Cancellation Policy: If you wish to cancel your registration, please contact the course coordinators, Susan Saba, ssaba@stanford.edu.