Nov
2
Thu
BMIR Research Colloquium: Teri Klein “Pharmacogenomics Knowledge for Personalized Medicine” @ MSOB, Conference Room X-275
Nov 2 @ 12:00 pm – 1:00 pm

Teri Klein
Teri Klein
Member of Academic Council
Professor (Research) of Biomedical Data Science and of Medicine (BMIR)
Stanford University

Abstract:

Pharmacogenomics (PGx) focuses on the use of genomic information to guide drug therapy and is a central component of precision medicine. Despite substantial progress in understanding how genetic variations impact drug efficacy and toxicity, the adoption of pharmacogenomics in clinical practice has been relatively slow. Major challenges in the implementation of pharmacogenomics knowledge include lack of awareness of the available evidence, unsure of how to interpret and use the genetic information, and lack of clear guidance on how to deliver information to the practitioners and patients. A central repository of pharmacogneomic knowledge is critical in addressing all of these challenges. The Pharmacogenomics Knowledgebase (PharmGKB) is a publically available premiere repository that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. Through our research efforts and collaborations with pharmacogenomics research and clinical communities, we provide a comprehensive catalogue of genes and genetic variations that are most important for drug response phenotypes.  I will describe the core content of our knowledgebase and discuss how we use the knowledge to support clinical implementation of PGx.  In addition, I will highlight our collaboration with the Clinical Pharmacogenetics Implementation Consortium (CPIC) to develop freely available, peer-reviewed gene/drug practice guidelines for physicians that aids implementation of pharmacogenetic testing and improves the precision of drug selection and dosing. Lastly, I will present the development of The Pharmacogenomics Clinical Annotation Tool (PharmCAT), a software tool that extract all CPIC level-A variants from a genetic dataset (represented as a vcf), interpret the variant alleles, and generate a report that can then be used to inform prescribing decisions

Klein

References

  • Whirl-Carrillo, E.M. McDonagh, J. M. Hebert, L. Gong, K. Sangkuhl, C.F. Thorn, R.B. Altman and T.E. Klein. “Pharmacogenomics Knowledge for Personalized Medicine”. Clinical Pharmacology & Therapeutics (2012) 92(4): 414-417.
  • V. Relling, T.E. Klein. “CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.” Clin Pharmacol Ther. 2011 Mar;89(3):464-7
Nov
27
Tue
ID Lecture Series: Febrile Neutropenia @ Li Ka Shing Center, LK304/5
Nov 27 @ 8:00 am – 9:00 am

Presenter: Jose G. Montoya, MD; Professor of Medicine (Infectious Diseases and Geographic Medicine) at the Stanford University Medical Center. Zoom Meeting ID: 790 915 319

Dec
20
Thu
ID Grand Rounds: “Is Herpes Simplex Virus a Wolf in Sheep’s Clothing?” @ Lane Building, L151
Dec 20 @ 4:00 pm – 5:00 pm

Presenter: Hector Bonilla, MD; Clinical Assistant Professor in Medicine – Med/Infectious Diseases. Zoom Meeting ID: 858 696 854

Apr
16
Tue
ID Lecture Series: Infections in HCT recipients @ Li Ka Shing Center, LK208
Apr 16 @ 8:00 am – 9:00 am

Presenter: Wes Brown, MD; Professor of Medicine (Blood and Marrow Transplantation) at the Stanford University Medical Center. Zoom Meeting ID: 790 915 319

Jun
2
Wed
SCCR Virtual Science Series: Vaccines: Lessons Learned or Errors Repeated in the time of COVID @ ZOOM Webinar
Jun 2 @ 9:00 am – 11:00 am
SCCR Virtual Science Series: Vaccines: Lessons Learned or Errors Repeated in the time of COVID @ ZOOM Webinar


Presenter: Dr. Philip Grant, MD

Click HERE to Register!

The mission of the Stanford Center for Clinical Research (SCCR) includes offering educational resources, training, and support for investigators and research staff.  We have invited the Assistant Professor of Medicine in the Division of Infectious Diseases, Dr. Philip Grant, MD, to provide you with an overview of the vaccines development and vaccine hesitancy for infectious diseases.

At the conclusion of this class, you will be able to:

  • Describe the history of vaccines development
  • Recognize the side effects of vaccines
  • Explain the history of vaccines hesitancy
  • Understand COVID-19 vaccines
  • Discuss vaccine hesitancy and COVID-19
  • Identify approaches to overcome vaccine hesitancy

Attendance is open to all research staff.

About the Instructor:

Dr. Philip Grant, MD, is a clinical researcher and Assistant Professor in the Division of Infectious Diseases. He is Director of the HIV Clinic at Stanford and has a long-standing research interest in optimizing antiretroviral therapy, HIV drug resistance, and minimizing toxicity for HIV and its therapy. He also is investigating the immune response to influenza and the management of chronic viral conditions in the developing world. During the COVID-19 pandemic, Dr. Grant has directed interventional clinical trials in hospitalized COVID-19 patients, COVID-19 vaccine studies, and a study looking at the long term health of patients previously infected with COVID-19.

BRN OPTIONAL 

Spectrum is an approved provider by the California Board of Registered Nursing, Provider Number CEP15435 for 2 contact hour(s).
To receive your certificate with BRN credit, you are required to complete an evaluation at the conclusion of this class.
BRN Cancellation Policy: If you wish to cancel your registration, please contact the course coordinators, Susan Saba, ssaba@stanford.edu.