Nov
2
Thu
BMIR Research Colloquium: Teri Klein “Pharmacogenomics Knowledge for Personalized Medicine” @ MSOB, Conference Room X-275
Nov 2 @ 12:00 pm – 1:00 pm

Teri Klein
Teri Klein
Member of Academic Council
Professor (Research) of Biomedical Data Science and of Medicine (BMIR)
Stanford University

Abstract:

Pharmacogenomics (PGx) focuses on the use of genomic information to guide drug therapy and is a central component of precision medicine. Despite substantial progress in understanding how genetic variations impact drug efficacy and toxicity, the adoption of pharmacogenomics in clinical practice has been relatively slow. Major challenges in the implementation of pharmacogenomics knowledge include lack of awareness of the available evidence, unsure of how to interpret and use the genetic information, and lack of clear guidance on how to deliver information to the practitioners and patients. A central repository of pharmacogneomic knowledge is critical in addressing all of these challenges. The Pharmacogenomics Knowledgebase (PharmGKB) is a publically available premiere repository that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. Through our research efforts and collaborations with pharmacogenomics research and clinical communities, we provide a comprehensive catalogue of genes and genetic variations that are most important for drug response phenotypes.  I will describe the core content of our knowledgebase and discuss how we use the knowledge to support clinical implementation of PGx.  In addition, I will highlight our collaboration with the Clinical Pharmacogenetics Implementation Consortium (CPIC) to develop freely available, peer-reviewed gene/drug practice guidelines for physicians that aids implementation of pharmacogenetic testing and improves the precision of drug selection and dosing. Lastly, I will present the development of The Pharmacogenomics Clinical Annotation Tool (PharmCAT), a software tool that extract all CPIC level-A variants from a genetic dataset (represented as a vcf), interpret the variant alleles, and generate a report that can then be used to inform prescribing decisions

Klein

References

  • Whirl-Carrillo, E.M. McDonagh, J. M. Hebert, L. Gong, K. Sangkuhl, C.F. Thorn, R.B. Altman and T.E. Klein. “Pharmacogenomics Knowledge for Personalized Medicine”. Clinical Pharmacology & Therapeutics (2012) 92(4): 414-417.
  • V. Relling, T.E. Klein. “CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.” Clin Pharmacol Ther. 2011 Mar;89(3):464-7
Dec
11
Tue
Women Faculty Networking Holiday Reception @ LKSC Berg Hall
Dec 11 @ 4:30 pm – 6:00 pm

Come enjoy hors-d’oeuvres, wine, and meet with your School of Medicine women faculty colleagues.

We are delighted to be joined by Special guests Lloyd Minor, MD and Linda Boxer, MD, PhD.

Please RSVP

RSVP to Kathleen Victor kvictor@stanford.edu.

Lloyd Minor, MD

Lloyd Minor, MD

Dean of the School of Medicine

Professor of Otolaryngology—Head & Neck Surgery and, by courtesy, of Neurobiology and Bioengineering

Lloyd B. Minor, MD, is a scientist, surgeon, and academic leader. He is the Carl and Elizabeth Naumann Dean of the Stanford University School of Medicine, a position he has held since December 1, 2012. He is also a professor of Otolaryngology–Head and Neck Surgery and a professor of Bioengineering and of Neurobiology, by courtesy, at Stanford University.

Linda Boxer

Dr. Linda Boxer

Vice Dean, School of Medicine

Professor of Medicine-Hematology

Linda M. Boxer, MD, PhD, is the Vice Dean, Stanley McCormick Memorial Professor in the School of Medicine, and Chief of the Division of Hematology. Dr. Boxer’s clinical expertise is in hematology malignancies. She serves as an attending physician on the inpatient hematology consult service. Dr. Boxer has mentored many trainees, especially physician scientists, and she has helped with their development into independent investigators.

 

Nov
6
Wed
Women Faculty Networking Lunch: Acting With Power @ Li Ka Shing Center - LK101
Nov 6 @ 12:00 pm – 1:30 pm
Register here.
Lunch will be provided.

This event is sponsored by the School of Medicine Office of Faculty Development and Diversity.

ACTING WITH POWER

Exploring your personal relationship to power, status and authority allows you to navigate nuanced organizational and communication dynamics with increased agility. This agility helps you accomplish your strategic, operational and professional objectives. Cultivating your Presence & Power requires alignment of self-perceptions and perceptions that others have of you. Expanding your authentic delivery range can change how we are perceived. Combining performance techniques and data from the fields of social psychology and gender research, this highly interactive session provides insight into how behavioral range – physical, vocal, intellectual, mindset, strategic – affects your impact. Objectives for the workshop may include:

  • Obtain deeper understandings of power, status and authority
  • Learn to observe and understand the behaviors that underlie power and
  • status dynamics
  • Learn how to use power constructively
  • Learn to use your voice and body most effectively
  • Learn to identify and use under-utilized parts of yourself
  • Develop a broader repertoire of useful verbal & non-verbal behaviors

Kay Kostopoulos directs and teaches acting, acting pedagogy, musical theater, voice, speech, and Shakespeare in the Department of Theater and Performance Studies (TAPS) and Continuing Studies Program at Stanford University. She teaches “Acting with Power” at Stanford’s Graduate School of Business, and has coached for the Knight Fellows Journalism Program, the Clayman Institute for Gender Research, and the Department of English. Kay has created and directed many training programs for Stanford’s School of Medicine.

She has also taught private seminars for Apple, Twitter, Airbnb, Genentech, Cisco, Sony Pictures, Hitachi, Thermo Fisher Scientific, Lippincott, Ernst and Young, First Republic, Stanford’s Executive Program for Women and Women in Entrepreneurship Program, eBay’s Global Women’s Conference and Women In Cable Telecommunications.  Her work has been featured in “O” magazine. http://www.oprah.com/spirit/Body-Language-Signs-Body-Language-of-Women/2and she has been featured on NPR’s Philosophy Talk radio program http://philosophytalk.org/shows/faces-feelings-and-liesfor her work on understanding facial emotions in the treatment of Autism.

Melissa Jones Briggs is a Lecturer at Stanford University’s Graduate School of Business. Trained as a theatre artist in London and New York, Jones Briggs specializes in performance as a tool for social change. She is a founding member of the teaching team for the renowned Acting with Power course at the GSB, she lectures in several Stanford Executive Programs, and coaches at the Clayman Institute for Gender Research. Melissa is especially passionate about inclusive leadership. Outside academia, Melissa designs, directs & deploys global leadership programs for corporations, NGOs, academic and federal institutions. As a speaker, she engages audiences around the world on topics like power, performance and inclusion. As a teaching artist, she developed devised performance curricula for underserved and severe special needs youth. She now serves as a Member of the Board of Directors at Youth in Arts, an arts education and social justice non-profit in the San Francisco Bay Area. Melissa studied at Wake Forest University, the Royal Academy of Dramatic Art, the Actors Center New York, and she has guest taught at London Business School, Aalto University in Helsinki, Finland and the United States Naval Academy.

Registration Open Until Tuesday, November 5, 2019 3:00 PM (EST)

Mar
4
Wed
Women Faculty Networking: Marc Tessier-Lavigne, President, Stanford University @ Li Ka Shing Center - LK209
Mar 4 @ 12:00 pm – 1:30 pm
Women Faculty Networking: Marc Tessier-Lavigne, President, Stanford University @ Li Ka Shing Center - LK209
Apr
1
Wed
Women Faculty Networking: Phil Pizzo, MD
Apr 1 @ 12:00 pm – 1:30 pm
Women Faculty Networking: Phil Pizzo, MD

Please join us with special guest Phil Pizzo, Former Dean, Stanford School of Medicine and Founding Director of the Stanford Distinguished Careers Institute, April 1, 2020, 12:00-1:30pm, location TBD. RSVP to Kathleen Victor.