Presenter: Andrew Elder, FRCP
Consultant Physician in Acute Medicine at Western General Hospital in Edinburgh
Honorary Senior Lecturer at the University of Edinburgh Medical School
(Please note: This event will be held in LKSC Room 130 due to a scheduling conflict)
Andrew Elder is a Consultant Physician in Acute Medicine for Older People in Edinburgh, Scotland, UK and an Honorary Professor at the University of Edinburgh Medical School, where he himself graduated as BSc in 1979 and MBChB in 1982.
He has held a number of positions relating to undergraduate and postgraduate medical teaching and assessment at local, national and international levels, and is currently Medical Director of MRCP(UK), which provides examinations in internal medicine and its specialties to over 25,000 candidates per annum globally. Prior to this, from 2008-2013, he was Chair of the MRCP(UK) Clinical Examining Board and responsible for the PACES examination – the largest international postgraduate clinical skills assessment in the world – and he has personally taught or assessed bedside clinical skills in around 20 different countries.
In 2013 he worked with Professor Abraham Verghese as a Visiting Associate Professor at Stanford University Medical School and was subsequently appointed as a Consultant to the Stanford Bedside Medicine programme and as a Visiting Professor to Stanford for 2015.
Postdoctoral Scholar,
Gentles Lab/Mackall Lab,
Stanford University
Uveal melanoma (UM) is the most common cancer of the adult eye and manifests as a highly aggressive form in approximately half of the patients. We performed a comprehensive landscape of genetic alterations in UM by integrating copy number alterations, transcriptomic and exome sequencing data across 207 primary UMs. Focal copy number analysis with the GISTIC algorithm refined the boundaries of chromosomal segments with chromosomal gains or losses and candidate cancer genes within segments of chromosomes 1, 2, 6 and 11 were identified. Using a complementary bioinformatics approach and incorporating data from exome sequencing, additional novel mutations in known dominant UM driver genes (GNAQ, GNA11, BAP1, SF3B1, EIFIAX and CYSLTR2) were identified. An accurate estimate of the frequencies of mutations in each gene were obtained. Finally, integration of data obtained from CNAs with transcriptome data from two datasets reveled two overlapping deleted loci, 6q and 1p36, which have historically been candidate loci for unidentified tumor suppressor genes. In conclusion, this study provides a comprehensive overview of the landscape of genomic alterations in UM and identifying novel candidate genes in regions of CNAs which could provide further insights into tumor development and progression in UMs.
Presenter: Jennifer Doudna, PhD
Professor of Chemistry, Biochemistry & Molecular Biology
Li Ka Shing Chancellor’s Professor in Biomedical and Health
University of California, Berkeley
Gene editing with CRISPR technology is transforming biology. Understanding the underlying chemical mechanisms of RNA-guided DNA and RNA cleavage provides a foundation for both conceptual advances and technology development. I will discuss how bacterial CRISPR adaptive immune systems inspire creation of powerful genome editing tools, enabling advances in both fundamental biology and applications in medicine. I will also discuss the ethical challenges of some of these applications with a focus on what our decisions now might mean for future generations.
As an internationally renowned professor of Chemistry and Molecular and Cell Biology at U.C. Berkeley, Doudna and her colleagues rocked the research world in 2012 by describing a simple way of editing the DNA of any organism using an RNA-guided protein found in bacteria. This technology, called CRISPR-Cas9, has opened the floodgates of possibility for human and non-human applications of gene editing, including assisting researchers in the fight against HIV, sickle cell disease and muscular dystrophy. Doudna is an Investigator with the Howard Hughes Medical Institute and a member of the National Academy of Sciences, the National Academy of Medicine, the National Academy of Inventors and the American Academy of Arts and Sciences. She is also a Foreign Member of the Royal Society, and has received many other honors including the Kavli Prize, the Breakthrough Prize in Life Sciences, the Heineken Prize, the BBVA Foundation Frontiers of Knowledge Award and the Japan Prize. She is the co-author with Sam Sternberg of “A Crack in Creation,” a personal account of her research and the societal and ethical implications of gene editing.
For further information: http://med.stanford.edu/radiology/imagining-the-future.html .
Please note this seminar is now cancelled and will be rescheduled for a future date. Please contact Ashley Williams (ashleylw@stanford.edu) with any questions or concerns. Thank you for your understanding!
Presenter: Elias Zerhouni, MD
Professor Emeritus
John Hopkins University
Abstract
In a career that spanned academia as a physician scientist, government as director of the NIH and then president of R&D for a global pharmaceutical company I share my experience and lessons learned on the way. While different in essence, academia, government and industry have symbiotic and complementary roles. The geopolitics of Research and development across the globe will be presented and their implications for biomedicine will be discussed along with the key emerging trends shaping the research agenda in the years to come across the changing landscape of healthcare. Personal advice on how best to navigate one’s career in these different environments will be shared.
About
Elias Zerhouni, M.D., Professor Emeritus Radiology and Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Dr. Zerhouni was most recently the President, Global Research & Development, and a member of the Executive Committee for Sanofi from January 2011 to July 2018.
Dr. Zerhouni’s academic career was spent at the Johns Hopkins University and Hospital where he was professor of Radiology and Biomedical engineering and senior adviser for Johns Hopkins Medicine. He served as Chair of the Russell H. Morgan Department of Radiology and Radiological Sciences, Vice Dean for Research and Executive Vice Dean of the School of Medicine from 1996 to 2002 before his appointment as Director of the National Institutes of Health from 2002 to 2008. In that position he oversaw the NIH’s 27 Institutes and Centers with more than 18,000 employees and a budget of $29.5 billion (2008).
In November 2009, President Obama appointed Dr. Zerhouni as one of the first presidential U.S. science envoys.
Dr. Zerhouni also served as senior fellow to the Bill and Melinda Gates foundation from 2009 to 2010 and senior advisor to the CEO of Sanofi.
Dr. Zerhouni has founded or co-founded five start-up companies, authored more than 200 publications and holds several patents. He has assumed positions on several Boards, including most recently, the board of the Lasker Foundation, Research!America and the NIH Foundation. He is also a member of the U.S. National Academy of Medicine and the U.S. National Academy of Engineering. He received the prestigious Legion of Honor medal from the French National Order in 2008, and was elected in 2010 as a member of the French Academy of Medicine and appointed as Chair of Innovation at the College de France in 2011.
For further information: http://med.stanford.edu/radiology/imagining-the-future.html .
Thursday, March 25, 2021, 10:00 AM – Friday, March 26, 2021, 2:50 PM PST
The 2021 Stanford Bedside Teaching Symposium is an annual event which brings together medical educators from around the world to foster clinical teaching skills. We aim to build a sense of community among all those who attend and to increase both individual physical examination skills as well as the ability of those in attendance to teach and evaluate the clinical skills of their learners. We accomplish this with lectures by expert clinicians, live demonstrations and workshops. The content is aimed at early and mid-career physician educators but would also be appropriate for chief residents and senior residents looking for a career in medical education.
*Tentative Agenda. Agenda times reflect Pacific Standard Time (PST)
Registration fee includes course materials and certificate of participation.
Registration Fees
Before 2/24/2021:
Attendees (Plenary and Workshops) – $100
Attendees (Plenary Only) – $50
Trainees and HBCU Faculty (Plenary and Workshops) – $100
Trainees and HBCU Faculty (Plenary Only) – $50
Lower Middle Income Country Resident (Plenary and Workshops) – $100
Lower Middle Income Country Resident (Plenary Only) – $50
(per World Bank, World Bank Developing Country List)
After 2/24/2021:
Attendees (Plenary and Workshops) – $200
Attendees (Plenary Only) – $100
Trainees and HBCU Faculty (Plenary and Workshops) – $100
Trainees and HBCU Faculty (Plenary Only) – $50
Lower Middle Income Country Resident (Plenary and Workshops) – $100
Lower Middle Income Country Resident (Plenary Only) – $50
(per World Bank, World Bank Developing Country List)