Apr
14
Thu
Research in Progress: Improving the Detection of Adverse Drug Events Mining the Biomedical Literature and Electronic Medical Records @ MSOB Conference Room X-275
Apr 14 @ 12:00 pm – 1:00 pm
Research in Progress: Improving the Detection of Adverse Drug Events Mining the Biomedical Literature  and Electronic Medical Records @ MSOB Conference Room X-275 | Stanford | California | United States

Presenter: Rainer Winnenburg, PhD
Postdoctoral Scholar, BMIR
Stanford University

About the Event:

In this talk, I will present recent progress in our attempt to apply Enrichment Analysis (EA) for pharmacovigilance. EA is a technique commonly used for identifying sets of genes that are over-represented in gene expression assays based on their annotation with terms from the gene ontology (GO). Here we use a generalized version of EA to identify significant associations between marketed drugs and adverse events from the biomedical literature (MEDLINE) to assist drug safety monitoring efforts. We assess how defining a selection of adverse event terms from MeSH, based on information content, can improve the detection of adverse events for drugs and drug classes.

In the second part of my talk, I will present a project in which we aim to leverage information from electronic medical records (EMR) to reduce the adverse drug event burden caused by polypharmacy. Several studies have shown that in some cases combinations of one drug with certain drugs from another drug class can lead to an increased risk of severe adverse events (ADEs) due to unintended drug-drug interactions (DDIs) while combinations with other drugs from the same class are not associated with an increased risk. We are currently working on an approach to detect ADE signals from clinical notes in EMRs in STRIDE (Stanford Translational Research Integrated Database Environment) that inform treatment adjustments for cohorts of patients concomitantly taking drugs from different drug classes with the goal of minimizing adverse effects and maximizing efficacy.

 

 

Mar
9
Thu
BMIR Research in Progress: Katie Quinn “Mining Observational Health Data to Discover Risky Multi-drug Combinations” @ MSOB, Conference Room X-275
Mar 9 @ 12:00 pm – 1:00 pm

Katie Q
Katie Quinn
Postdoctoral Scholar
Shah Lab, Stanford University

Abstract:

Concurrent use of multiple prescription drugs is widespread, with over 10% of Americans currently prescribed 5 or more drugs. Adverse drug reactions result in significant morbidity, and a substantial proportion of these are known to be caused by drug-drug interactions. Whereas premarket safety trials of all common drug combinations are infeasible, large-patient observational health data may enable postmarket surveillance of multi-drug safety.

We aim to identify associations between multi-drug combinations and health outcomes using the Truven Health MarketScanⓇ Databases, which document health coverage for approximately 100 million Americans over a median of 2 years. We first rank the incidence of concurrent drug prescriptions, to discover common multi-drug combinations. We then focus on a study of associations between these common multi-drug combinations and Emergency Department visits. We explore simple both disproportionality analysis and self-controlled case series study designs, and methods for empirical calibration in the absence of gold-standard controls.

 

May
16
Tue
Center for Population Health Sciences Guest Lecturer: Roger Thurow @ Encina Commons, Room 117
May 16 @ 11:00 am – 12:00 pm
Center for Population Health Sciences Guest Lecturer: Roger Thurow @ Encina Commons, Room 117 | Stanford | California | United States

Roger Thurow
Senior Fellow, Global Food Agriculture
The Chicago Council on Global Affairs
Event Information and Registration

Please join us in welcoming Roger Thurow who will be visiting Stanford on the eve of his most recent publication, the First 1000 Days.  Through compelling stories of new mothers and babies in Uganda, India, Guatemala, and Chicago, award-winning journalist and anti-hunger advocate explores the promise of—and confounding challenges to—a transformative worldwide initiative to end early childhood malnutrition.

Oct
19
Thu
BMIR Research in Progress: Azadeh Nikfarjam “Drug Safety Information Extraction from Social Media” @ MSOB, Conference Room X-275
Oct 19 @ 12:00 pm – 1:00 pm

azadeh-nikfarjam

Azadeh Nikfarjam
Postdoctoral Scholar
BMIR, Stanford University

ABSTRACT:
Adverse drug reactions (ADRs) are a major public health concern and are among the top causes of morbidity and mortality. Many ADRs, are not identified in pivotal clinical trials and initial drug labels. Post-market drug surveillance platforms such as FDA monitoring rely on voluntary, spontaneous reporting and lack temporal advantage over literature. Thus, practitioners on the frontlines of novel treatments, particularly cancer treatments, operate in the dark conducting ADR surveillance. There is a critical need for timely and accurate detection of ADRs in the post-approval period. Internet community health forums provide a robust social platform for individuals to discuss real-time health concerns and may serve as a resource for computational detection of drug safety-related information. We demonstrate the use of a natural language processing pipeline to identify ADR signals from Inspire, one of the leading health forums, to compare user reporting of ADRs with clinical reporting

Mar
13
Wed
SCCR Coordinator Brown Bag: Work Purpose and Career Paths @ LK209
Mar 13 @ 9:00 am – 10:00 am
SCCR Coordinator Brown Bag: Work Purpose and Career Paths @ LK209

Department of Medicine Managers and Coordinators,

Please join us for the first SCCR Coordinator Brown Bag for 2019 on Wednesday, March 13th, 2019 from 9:00-10:00 am in LKSC Room 209.

Meet your fellow coordinators, receive updates and announcements, share best practices – and enjoy breakfast among colleagues! SCCR will be hosting quarterly Brown Bag meetings in 2019. Future dates will be provided in the near future.

Please RSVP HERE by end of day Monday, March 11, 2019

Breakfast will be provided

Date: Wednesday, March 13, 2019

Time: 9:00-10:00 am

Location: LKSC 209

Topic: “Work Purpose and Career Paths”

Fulfillment, Satisfaction, Engagement, name it; why does it matter to have clarity around our work purpose? Let’s gather at this Brown Bag workshop to discuss and share our thoughts and our experiences on what makes our work worthwhile, and how that defines the career paths we’re on!

Moderator: Susan Saba, MPH

 

 

Visit SCCR Events HERE