“Chemical probes for imaging proteases and hydrolyses involved in cancer and infectious diseases”
Matthew Bogyo, PhD
Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems Biology
Stanford University
Location: Zoom Webinar
Webinar URL: . https://stanford.zoom.us/s/96278232036
Dial: +1 650 724 9799 or +1 833 302 1536
Webinar ID: 962 7823 2036
Passcode: 024008
ABSTRACT
Hydrolases are enzymes (i.e. proteases, esterases, lipases) that often play pathogenic roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Therefore, tools that allow dynamic monitoring of their activity can be used as diagnostic agents, as imaging contrast agents and for the identification of novel enzymes as drug leads. In this presentation, I will describe our efforts to design and build small molecule probes that can be used to identify, inhibit and image various hydrolase targets in models of cancer and infectious disease. This will include recent advances in protease activated fluorescent probes for real-time visualization of tumors during surgery as well our efforts to identify several new classes of serine hydrolases in pathogenic and commensal bacteria. We believe many of these enzymes will represent valuable imaging and therapy targets that can be used to visualize and disrupt various aspects of colonization and community formation inside a host.
ABOUT DR. BOGYO
Dr. Bogyo is a Professor of Pathology and Microbiology and Immunology at Stanford University. He received his bachelor’s degree in Chemistry from Bates College in 1993 and a doctorate in Chemistry from Massachusetts Institute of Technology in 1997. Dr. Bogyo established an independent scientific career as a Faculty Fellow at the University of California, San Francisco, where he supervised a small laboratory of post-doctoral fellows and students. In 2001, Dr. Bogyo was hired to establish and direct the Chemical Proteomics Department at Celera Genomics focused on applying small molecule probes to the field of drug discovery. Dr. Bogyo then joined the Department of Pathology at Stanford University in July 2003 and was promoted to Associate Professor in 2009 and to full professor in 2013. His laboratory works on the development of new chemical probe technologies that are applied to study the role of proteases in complex biological pathways associated with human disease. Dr. Bogyo has published over 250 primary research publications and currently serves on the Editorial Board of several prominent research journals. He was the President of the International Proteolysis Society from 2007-2009 and chair of the Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors in 2018 and the Imaging in 2020 meeting in 2016. Dr. Bogyo is also a member of Stanford’s Comprehensive Cancer Center, the Molecular Imaging Program at Stanford (MIPS) and is a consultant for several biotechnology and pharmaceutical companies in the Bay Area. He is the recipient of numerous awards including the Searle Scholar Award, The Terman Fellowship and the Burroughs Wellcome Investigators in Pathogenesis award. He is the co-founder of Akrotome Imaging, a small start up company developing imaging contrast agents for detection of surgical margins.
Hosted by: Katherine Ferrara, PhD
Sponsored by: Molecular Imaging Program at Stanford & the Department of Radiology